NANOSPECTROSCOPY FOR NANOMATERIALS AND NANOBIOMEDICINE

Computational Nanospectroscopy on Fundamental Atomic and Molecular Scales

Anil Pradhan, Sultana Nahar, Rusell Pizer, Max Montenegro, Yan Yu, Jian Wang, Li Kaile, Neil Jenkins

Spectroscopy is the most powerful tool for the study of matter at fundamental atomic and molecular scales -- the natural and most basic limits of nanoscience and nanotechnology. Each element or compound has a unique spectral signature. Physical and chemical properties of materials and medicines must be underpinned by studies of constituent atoms and molecules and their interactions with electromagnetic radiation at all wavelengths from Infrared to X-ray. Such studies will provide the foundation for basic understanding as well as practical applications for (A) the construction of new composite nanomaterials, and (B) radiation diagnostics and therapy using nanomedicine.

The interdisciplinary Computational Nanospectroscopy program is based on atomic resonant phenomena. RESONANCE TARGETED STUDIES OF ATOMIC AND MOLECULAR SYSTEMS REVEAL THE PRECISE ENERGIES WHERE RADIATION INETRACTIONS WITH NANOMATERIALS OR NANOMEDICINE WILL BE MOST EFFECTIVE IN ALL ELEMENTS OF THE PERIODIC TABLE.

Ongoing research include theoretical and experimental studies under the RESONANT NANO-PLASMA THERANOSTICS (RNPT) project. The basic idea is to utilize monochromatic X-ray sources for imaging and therapy, rather than the conventional broabdand bremsstrahlung X-ray sources used in nearly all medical applications. Recent Publications include: ``Resonant X-Ray Enhancement of the Auger Effect in High-Z atoms, molecules, and Nanoparticles: Biomedical Applications" (Pradhan etal. 2009), ``Monte Carlo Simulations and Atomic Calculations for Auger Processes in Biomedical Nanotheranostics" (Montenegro etal. 2009), and "``RESONANT THERANOSTICS: A New Nano-Biotechnological Method for Cancer Treatment Using X-ray Spectroscopy of Nanoparticles" (Nahar etal. CRC Press 2011).